The Dominican Sisters Cabra have a long history in South Africa, celebrating their 150th anniversary in the country in 2013. Providing education in schools and education to deaf children across the region has been the principal mission of the Sisters over their history. A range of primary schools, secondary schools and schools for the Deaf were established in Capetown, in the Eastern and Western Capes and in Gauteng. These schools have now been placed into trust with lay people who continue educate numerous pupils in accordance with the Dominican ethos.
The Dominican Sisters in South Africa are now committed to their work in the Justice area, responding to the needs of providing a more just society, following on from their work against apartheid.